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Biological evaluation indicated that both 1 and 2 could restrict renal fibrosis in TGF-β1-induced kidney proximal tubular cells.Acute mountain sickness (AMS) impacts more or less 25-50% of newcomers to large altitudes. Two human carbonic anhydrase isoforms, hCA I and II, play key roles in building high altitude illnesses. Nonetheless, truly the only FDA-approved drug for AMS is acetazolamide (AAZ), which has a nearly 100 times weaker inhibitory activity against hCA we (Ki =