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BACKGROUND Internet data can be used to improve infectious disease models. However, the representativeness and individual-level validity of internet-derived measures are largely unexplored as this requires ground truth data for study. OBJECTIVE This study sought to identify relationships between Web-based behaviors and/or conversation topics and health status using a ground truth, survey-based dataset. METHODS This study leveraged a unique dataset of self-reported surveys, microbiological laboratory tests, and social media data from th