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The Most Effective ADHD Medication For Adults Adults with ADHD are typically prescribed stimulants. They aid in adjusting levels of two chemical messengers within the brain that regulate the ability to pay attention. Strattera (atomoxetine) is the most effective adhd medication available for adults. It is available in a capsule that can either be taken with food or without. It is effective for a majority of people. It also lasts longer than the shorter-acting stimulants, such as amphetamine and methylphenidate. 1. Strattera Strattera (atomoxetine) i