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The PN Panel showed a sensitivity of 100% for 15/22 etiologic targets using BAL specimens and 10/24 for sputum specimens. All other targets had sensitivities of ≥75% or were unable to be calculated due to low prevalence in the study population. Specificity of all targets was ≥87.2%, with many false positive results compared to culture that were confirmed by alternative molecular methods. Appropriate adoption of this test could provide actionable diagnostic information that is anticipated to impact patient care and antimicrobial steward