https://www.selleckchem.com/pr....oducts/LY315920(Vare
o seen in the hippocampus of both Line 1 and Line 66. in Line 1 mice confirms the Alzheimer's disease-like phenotype in Line 1 mice, whilst Line 66 revealed no measurable change in total cholinergic expression, a phenotypic trait of frontotemporal lobar degeneration. These two transgenic lines are therefore suitable for discriminating mechanistic underpinnings between the Alzheimer's and frontotemporal lobar degeneration-like phenotypes of these mice.Therapeutic trials of disease-modifying agents in neurodegenerative disea
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