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ren of grandparents who were aged 25 to 29 years at the time of giving birth to the parents. Conclusions and Relevance These findings corroborate previous studies suggesting that advanced parental age is independently associated with increased ASD risk in children. This study also found that children with young maternal grandparents and children with young and old paternal grandparents had elevated ASD risk. Possible transmission of ASD risk across generations should be considered in etiological research on ASD.Importance Much research