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the control group (86 ± 12 m vs. 32 ± 6 m, 0.001). Several other physical parameters were significantly improved in the intervention group. Global self-esteem and parent-reported quality-of-life were significantly increased in the intervention group. Analysis at T0 + 12 mo showed persistence of the benefits in the intervention group on exercise capacity evolution (115 ± 18 m vs. 49 ± 11 m, = 0.004) and on most physical and QoL parameters. In children and adolescents with cancer, a physical activity program is safe, improve