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Increasing evidence has indicated that long non‑coding RNAs (lncRNAs) serve an essential role in carcinogenesis and cancer development. It has been reported that lncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT‑AS1) serves a crucial role in several types of cancer. However, the clinical significance of circulating NNT‑AS1 expression in colorectal cancer (CRC) remains to be elucidated. The current study aimed to investigate the potential role of NNT‑AS1 and the clinical significance of its serum expression levels in pa