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SUMMARY In sum, both microneedling and mesoneedling are effective in lowering melanin content when you look at the epidermal melasma lesions. © 2020 Wiley Periodicals, Inc.We report a genomics-guided exploration associated with metabolic potential of the brasilicardin producer strain Nocardia terpenica IFM 0406. Bioinformatics analysis of the whole genome sequence unveiled the existence of a biosynthetic gene group apparently responsible for the generation of previously unidentified nocobactin der