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Health Issues That Affect German Shepherd Life Expectancy German Shepherds reach their peak between ages 2 and 6. The German Shepherd is at its best in terms of physical and mental sharpness. Their size puts them at a greater risk of developing cancer muscle and joint issues, and other health conditions that may affect their lifespan. Working line German Shepherds often have a more active lifestyle than their show line counterparts. They require a nutrient-rich diet to help them meet their activity leve