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The aim of this work was to conduct a systematic review on psychological behavior in the context of pandemic scenarios during the twenty-first century. We focused on empirical works and brief case reports of H1N1 flu and COVID-19. Our review included 32 papers published both in English or Spanish. We built a set of tables that allowed us to classify the information in four main categories, namely the psychological impact of the pandemic, whether people follow or not official measures to protect themselves against the pandemic, psycholo