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Subgroup analyses and quality ratings were performed. After problem-solving therapy, the depression scores in the intervention group were significantly lower than those in the control group (SMD = -1.06, 95% CI -1.52 to -0.61, p 0.05; I = 88.4%). Compared with waitlist (WL), PST has a significant effect on elderly patients with depression, but we cannot rank the therapeutic effects of all the treatment methods used for MDD. Our meta-analysis and systematic review suggest that problem-solving therapy may be an effective approach to