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Behçet disease (BD) is an immune-mediated vasculitis-like syndrome characterized by recurrent aphthous lesions and various systemic manifestations. Inflammatory markers may be useful to assess disease severity. The Systemic Immune-Inflammation Index (SII) (neutrophils×platelets/lymphocytes) has been widely used in oncology since 2014, with promising results. To assess the efficiency of the SII in determining activity of BD. This retrospective cohort study was conducted on patients with BD who were admitted to the outpatient clinic of the