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Paracoccidioidomycosis is a dimorphic fungal infection endemic in Latin America. We report a patient with a history of pulmonary paracoccidioidomycosis who presented with relapsed disease in the central nervous system 4 years after initial treatment. We review current treatment strategies for paracoccidioidomycosis and neuroparacoccidioidomycosis. © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. U
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