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Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677T gene polymorphism and COVID-19 incidence and mortality worldwide. Data regarding MTHFR C677T gene mutation were obtained from the interrogation of the Genome Aggregation Database (genomAD), which is publicly available from the web"https//gnomad.broadinstitute.org." COVID-19 cases, including prevalence and mortality, were obtai
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