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Copyright © 2020 Gim, An, Sung, Silverman, Cho and Won.Multiple sclerosis (MS) is an autoimmune disease for which it is difficult to find exact disease-related genes. Effectively identifying disease-related genes would contribute to improving the treatment and diagnosis of multiple sclerosis. Current methods for identifying disease-related genes mainly focus on the hypothesis of guilt-by-association and pay little attention to the global topological information of the whole protein-protein-interaction (PPI) network. Besides, network rep