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These genes were mainly involved in cell proliferation and cell cycle. Among them, 15 genes including were found to be strongly associated with the PPI network. We further performed immunohistochemistry, qRT-PCR and Western blotting to identify that expression was higher in CRC than in paired normal tissues. Moreover, in vitro and in vivo experiments demonstrated could promote the proliferation, invasion and migration of colorectal cancer cells. could be considered as a potential biomarker for CRC patients. GINS1 could be considered as a p
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