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To evaluate the efficacy of intramuscular methylergonovine maleate as prophylaxis against excessive bleeding when given after dilation and evacuation (DE) at 20-24 weeks. We performed a randomized, double-blinded, placebo-controlled trial in patients without excessive bleeding requiring intervention after DE completion. We administered study treatment within one minute of the end of the procedure. We primarily compared outcomes using a composite of indicators of excessive post-procedure blood loss (post-procedure measured bl