https://hormones-receptor.com/....index.php/low-freque
Non-peptide CRF1R-selective antagonists have already been proven to use anxiolytic and antidepressant effects on experimental creatures. But, not one of them is in clinical use today because of several unwanted effects, therefore showing the need for the development of other more ideal CRF1R antagonists. In order to develop novel CRF1R antagonists we designed, synthesized and chemically characterized two tripeptide analogues of CRF, particularly (R)-LMI and
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