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2%) than loss of MSH2/MSH6 (n = 81/705, 11.5%; P less then .0001), and was associated with lower mean TMB (MLH1/PMS2 25.03 mut/Mb vs MSH2/MSH6 46.83 mut/Mb; P less then .0001). TMB also varied by tumor histology colorectal cancers demonstrating MLH1/PMS2 loss had higher TMBs (33.14 mut/Mb) than endometrial cancers (20.60 mut/Mb) and other tumors (25.59 mut/Mb; P less then .0001). MMR gene mutations were detected in 42.0% of tumors; among these, MSH6 mutations were most common (25.7%). MSH6 mutation patterns showed variability by tumor hi
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