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BACKGROUND The present study aimed to assess the association of various age groups with survival in patients with glioblastoma. MATERIAL AND METHODS The Surveillance, Epidemiology, and End Results (SEER) database was used to extracted data on new diagnoses of glioblastoma between 2005 and 2015. Four age models were constructed according to the age at diagnosis. RESULTS A total of 28 734 patients with glioblastoma (16 823 men and 11 911 women) were enrolled in the study. In multivariate analysis, variables including sex, race, tumor, and cl