https://iap-signal.com/index.p....hp/within-population
In this work, we provide a mechanistic modeling aided approach that paves the way for an accelerated growth of anionic mixed-mode chromatography (MMC) for biopharmaceutical purification. A modified multimodal isotherm model had been calibrated using only three chromatographic experiments and ended up being employed in the retention prediction of four antibody formats including a Fab, a bispecific, along with an IgG1 and IgG4 antibody subtype at pH 5.0
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