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MPTP models have been developed to mimic human Parkinson's disease and serve as an indispensable tool for studying PD. Among them, subacute MPTP PD models are popular due to their short modeling period and similarity to PD pathology. However, the early pathophysiological mechanism of the model remains to be further clarified. More and more studies have shown that dysregulation of miRNAs plays an important role in the occurrence and development of neurodegenerative diseases, including PD. In this study, we identified 43 differentially exp