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How Does ADHD Medication Work? When a neuron transmits a message to another neuron, it uses chemicals called neurotransmitters. These need to cross a tiny gap called a synapse. Certain ADHD medications increase the efficiency of these messages. They may assist neurons in the release of more neurotransmitters or slow down the process of reuptake (called reuptake inhibitors). Doctors start people with ADHD with a low dose of medication and then observe their
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