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The results also show that all of the improvements began to slightly decrease at 1200 kg/m3 of the binder content. On the other hand, it was concluded that SC resulted in higher mechanical performance and ductility behavior than WC.Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a