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Although natural and bioinspired computing has developed significantly, the relationship between the computational universality and efficiency beyond the Turing machine has not been studied in detail. Here, we investigate how asynchronous updating can contribute to the universal and efficient computation in cellular automata (CA). First, we define the computational universality and efficiency in CA and show that there is a trade-off relation between the universality and efficiency in CA implemented in synchronous updating. Second, we intr