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Two green, simple, and accurate chromatographic methods were developed and validated for the simultaneous determination of omeprazole and aspirin mixture in the presence of salicylic acid, a major impurity of aspirin. Method A is a reversed-phase ultra-high-performance liquid chromatography; the separation was performed on a C18 column, with a mobile phase composed of ethanol0.1% aqueous solution of triethylamine acidified with orthophosphoric acid (pH 3) (3070, v/v) at 0.15 mL/min flow rate and 230 nm. Omeprazole, aspirin, and aspirin i
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