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Summary Better understanding of pathogenic pathways together with an accurate phenotype classification of patients presented with rhinitis symptoms contributes to point out clinical usefulness of biomarkers and other diagnostic tools, which leads to more accurate environmental control measures, personalized pharmacologic options, and new biological therapy developments. © Springer Nature Switzerland AG 2020.We performed sequence diversity, phylogenetic profiling, 3D structure modelling and in silico interactions between invertases (cell w

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