https://www.selleckchem.com/pr....oducts/Abitrexate.ht
This conclusion was supported by significantly reduced expression of selected NF-κB-dependent genes cyclin D1 (CCND1), C-X-C motif chemokine ligand 8 (CXCL8), and vascular endothelial growth factor (VEGF), as shown at transcript and protein levels, as well as secretion of IL-8 and VEGF. Our study indicates that 17-aminogeldanamycin can be used for efficient inhibition of NF-κB activity and the simultaneous diminution of IL-8 and VEGF levels in the extracellular milieu of melanoma.The purpose of the present study was to determine the
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