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The discovered pyrazolopyridine derivatives were examined theoretically by molecular docking, and also this research exhibited appropriate binding involving the energetic sides of pyrazolopyridine ligands and proteins (PDB ID 5IVE). The pyridopyrazolo-triazine compound 6a revealed the greatest free binding energy (- 7.8182 kcal/mol) whenever docked within the energetic website of selected proteins.Epilepsy is a common and severe neurological condition