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The incidence of MACE (37.5% vs. 5.5%; P  0.001) and TLR (37.5% vs. 5.0%; P  0.001) is higher in the E-ISR group. After multivariate analysis, E-ISR (odds ratio [OR], 13.267; [95% CI 4.984-35.311]; P  0.001) and left ventricular systolic dysfunction (odds ratio [OR], 6.317; [95% CI 1.145-34.843]; P = 0.034) are the independent predictors for MACE among DES-ISR patients in the mid-term follow-up of 12 months. Early ISR and left ventricular systolic dysfunction are associated with MACE during the mid-term follow-up period for DES

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