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In transgenic mice with cardiac overexpression of kinase-dead mutant Mst1 gene, these adverse cardiac effects of DOX had been significantly attenuated relative to wild-type littermates. Conclusions Anti-cancer activity of both DOX and verteporfin is associated with Hippo pathway activation. Such activity on cardiac Hippo path mediates mitochondrial damage and cardiomyopathy.Computed tomography (CT), a diagnostic tool with medical application, comprehensive coverage, and cheap, is employed

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