https://www.selleckchem.com/products/azd5582.html
Live oral rotavirus vaccines have been developed by serial passaging in cell culture and found safe in infants. However, mechanisms for the adaptation and attenuation of rotavirus vaccines are not fully understood. We have prepared a human rotavirus vaccine strain CDC-9 (G1P[8]) which when grown in MA104 cells to passages 11 or 12 (P11/P12), had no nucleotide and amino acid sequence changes from the original virus in stool. Upon adaptation and passages in Vero cells, the strain underwent five amino acid changes at passage 28 (P28) and o
Like
Comment
Share
