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The models had been placed on 513 pwMS and 208 healthier settings (HC) from 7 different facilities. Versions had been analyzed making use of structural harm, international diffusion properties, clinical impairment , intellectual scores, and graph-derived metrics from both simulated and empirical FC. For the stable design, higher SC-FC coupling was associated with pwMS with reasonable Single Digit Modalities Test (SDMT) score (F=3.48, P$\lt$0.05), suggesting that cognitive impairment in pwMS is