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However, the indicators that advertise the development and upkeep among these stem-like CD8+ T cells (CD8+SL) remain badly defined. Studying CD8+ T cellular differentiation in mice with chronic viral infection, we identified the alarmin interleukin-33 (IL-33) as pivotal when it comes to development and stem-like performance of CD8+SL and for virus control. IL-33 receptor (ST2)-deficient CD8+ T cells exhibited biased end differentiation and untimely lack of Tcf-1. ST2-deficien
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