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We compared PRS constructions for eGFR prediction in Hispanic/Latino individuals utilizing GWAS-significant variants, clumping and thresholding (CT),8 and PRS-CS,22 along with a mixture of PRSs calculated with different reference GWAS meta-analyses from European and multi-ethnic researches in Hispanic/Latino people from the Hispanic Community wellness Study/Study of Latinos (HCHS/SOL). All eGFR PRSs were highly associated with eGFR (p less then 1E-2. Furthermore, eGFR PRSs were somewhat associated with lower danger of prevalent
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