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1 log c/mL, p=0.01; week 24 3.7 vs. 4.9 log c/mL, p less then 0.001). The performance of a multivariable model based on HBV RNA levelwas comparable at week 12 (AUC 0.68)and 24 (AUC 0.72) of therapy. HBV RNA level above 5.5 log c/mL at week 12 showed negative predictive values of 93/67/90/64% for HBV genotypes A/B/C/D for the prediction of HBeAg loss. In conclusion, HBV RNA in serum declines profoundly during PEG-IFN treatment. Early on-treatment HBV RNAlevel may be used to predict non-response. This article is protected by copyright. Al
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