https://apoptosissignal.com/in....dex.php/distinction-
Formerly synthesized compounds considering the 4-aminoquinoline core hybridized with a chemosensitizing dibenzylmethylamine part group showed in vivo efficacy in Plasmodium berghei-infected mice despite reduced microsomal metabolic stability, recommending a contribution from their pharmacologically active metabolites. Here, we report on a series of these dibemequine (DBQ) metabolites with low resistance indices against chloroquine-resistant parasites a
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