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How Does Medication For ADHD Work? Stimulants increase the levels of dopamine and norepinephrine in your brain, helping improve the ability to focus and control impulses. They come in immediate-release (short-acting) and extended-release tablets, which are taken twice a day, typically in the morning. Nonstimulant medicines take longer to work but can also improve the ability to control impulses and attention. Atomoxetine, Viloxazine and guanfacine are antidepressants that raise levels of norepinephrine. Stimulants The most commonly utilized