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The Most Effective ADHD Medication For Adults Adults with ADHD are usually prescribed stimulants. They regulate the levels of two chemical signals in the brain that regulate attention. Strattera (atomoxetine) is the most effective treatment for adhd available for adults. It is an oral capsule that can be taken with or without food. It is effective for a majority of people. It also lasts longer than the less powerful stimulants, like methylphenidate or amphetamine. 1. S