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Thus, WMTI model metrics are shown to be promising candidates as sensitive biomarkers of demyelination. Limited information exists regarding the association between midlife lipid levels and late-life total and regional brain volumes. We studied 1872 participants in the longitudinal community-based Atherosclerosis Risk in Communities Neurocognitive Study. Serum lipid levels were measured in 1987-1989 (mean age, 53±5 years). Participants underwent 3T brain MRI scans in 2011-2013. Brain volumes were measured using FreeSurfer image analysi
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