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12)-2.66]). Total WOMAC score showed a significant difference over the time favoring HA injection (4.5 [95%CI 1.1-8]). However, no single time point showed any significant difference between groups. This meta-analysis showed no significant difference between HA and ozone in reducing pain and improving function in patients with knee OA, although the overall results favored HA over ozone. Since previous studies have shown comparable results between HA and placebo, ozone seems to fall in the same category with more placebo effect rather th

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