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Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a kind of very rare idiopathic disease. The most common feature is the excessive accumulation of Langerhans cells in lymph nodes, but it may also occur in other areas and lead to related organ damage. We report a case of a 60-year-old man with Rosai-Dorfman disease, which led to dyspnea. Surgery is the best treatment to relieve the patient's dyspnea in a short time. Rosai-Dorfman disease has trend to self-healing, but in the case of special locati

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