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In conclusion, our results point out the importance of ensuring continuity of care for children with NDD (e.g. telehealth) during home confinement and of providing psychological support for parents. We aimed to build a modified systemic inflammatory score(mSIS) based on preoperative albumin, fibrinogen, lactate dehydrogenase, and neutrophil-lymphocyte ratio in patients with high-grade glioma. Data of 318 patients with high-grade gliomas were retrospectively analyzed. The SIS was developed and its associations with clinicopathological feat