https://www.selleckchem.com/pr....oducts/myf-01-37.htm
Analytical performance of stable isotope labeled internal standardization (SIL-IS) and threshold accurate calibration (TAC) methods of matrix normalization are compared for quantitation of 51 drugs and metabolites (analytes) in urine with analysis by UPLC-MS-MS. SIL-IS was performed with both analyte-specific (ASIL-IS) and shared (SSIL-IS) internal standards. Variance in inter-specimen matrix effect, without use of a matrix normalization method, was studied by UPLC-MS-MS (Ultra Performance Liquid Chromatography with tandem mass spectr
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