https://www.selleckchem.com/pr....oducts/--mk-801-male
However, inhibition of miRNA-17-5p showed the opposite effect. Ago2 IP and luciferase assay revealed that miRNA-17-5p directly bound to the 3'UTR of VIM mRNA. Furthermore, miRNA-17-5p inhibited the metastasis of CRC into liver in vivo. Conclusions Our results demonstrated that miRNA-17-5p regulates vimentin expression, thereby regulating metastasis of CRC.Background Subcutaneous mouse tumour models are widely used for the screening of novel antitumour treatments, although these models are poor surrogate models of human cancers.
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