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Background Numerous meta-analyses have been conducted on music and pain, but no studies have investigated music and cardiac procedural pain. Objective To assess the effects of music intervention on pain in cardiac procedures in the published randomized controlled trials. Methods This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All the included randomized controlled studies were published between 1999 and 2016. Studies were obtained from electronic databases or by ha