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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are first-choice ADHD medications, they have the most research-based backing behind them, and they are quick-acting. But they're not right for everyone. These medications increase the signaling between nerves and the regions of the brain to reduce symptoms of ADHD. These medications can also cause side-effects like a change in heart rate or blood pressure as well as a loss of appetite. Stimu