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How Does Medication For ADHD Work? Stimulants can increase your ability to concentrate and control impulses by increasing the levels of dopamine and norepinephrine within your brain. They come in immediate-release (short-acting) and extended-release tablets that are taken every day, typically in the morning. Nonstimulant medications take longer to work but they can also enhance concentration and control of impulses. Atomoxetine, Viloxazine and guanfacine are antidepressants that