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Despite the worries of its drug-resistance as well as other problems, Triclosan continues to be a fruitful medicine against numerous infectious organisms. Understanding the cross-interactions of Triclosan with different antibiotics, bacteria, and people can provide necessary information for the risk evaluation of the medicine. We examine current understanding of the antimicrobial systems of Triclosan, just how microbes come to be resistant to Triclosan, therefore the synergistic and antagonistic results of Triclosan